Assistant Professor Stefan Stoll has received a CAREER (Faculty Early Career Development) Award from the National Science Foundation. The CAREER Program is a Foundation-wide program that “offers the National Science Foundation’s most prestigious awards in support of junior faculty who exemplify the role of teacher-scholars through outstanding research, excellent education and the integration of education and research within the context of the mission of their organizations.”
Stoll uses an experimental biophysical approach to pursue a deeper understanding of the molecular structure and dynamics of protein-protein and protein-ligand interactions that underlie the mechanisms of all chemical processes in life. His NSF CAREER Award research proposal, “CAREER: Elucidating conformational landscapes in proteins using high-sensitivity pulse EPR spectroscopy,” will use high-sensitivity double electron-electron resonance (DEER) spectroscopy—a pulsed electron paramagnetic resonance (EPR) technique that measures nanometer-scale distances between spin labels attached to proteins, allowing the determination of conformational distributions and flexibility in a manner unattainable by other methods—to quantitatively elucidate the conformational distributions in a model protein and in an ion channel.
Stoll’s project will advance understanding of the dynamics of protein host and ligand interactions and the regulation thereof on a molecular level. The foundational knowledge gained through this work is a key prerequisite to the rational design of new drugs and therapies, and the experimental insights will inform ongoing efforts to develop models of protein-protein interactions. The innovative EPR spectroscopic techniques being developed by Stoll are transformational, and will open up a broad range of new possibilities for probing molecular structure and dynamics.
For more information about the NSF CAREER Award program, please visit the program website.
For more information about Professor Stoll and his research, please visit his faculty page and research group website.
Assistant Professor Stefan Stoll (Chemistry), Professor William Zagotta (Physiology & Biophysics), and co-workers have used double electron-electron resonance (DEER) spectroscopy to determine the structural origins of the regulatory function of cyclic adenosine monophosphate (cAMP) on an important ion channel. Their work reveals that binding of the cAMP induces a large structural change in the intracellular part of the channel. The ion channel studied, a hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channel, is critical to the function of heart, as it is part of the heart’s natural pacemaker. The HCN channel is crucial in regulating the heartbeat: binding of cAMP to HCN increases of the heart rate. This work, reported in the Proceedings of the National Academy of Sciences, could form the basis for better drug design for disorders of electrical signaling in the heart. (A movie showing a model of the structural change can be downloaded in Quicktime format from: http://felix.chem.washington.edu/HCN_DEER_movie.mov.)
To learn more about Professor Stoll and his research, please visit his faculty page and research group website.
To learn more about Professor Zagotta and his research, please visit his faculty page.
Applications are invited for full-time, tenure-track appointments in the Department of Chemistry. Outstanding candidates in all areas of chemistry and interdisciplinary areas involving chemistry will be considered for appointment at the Assistant, Associate, and Full Professor levels. We especially welcome applications in the areas of analytical, inorganic, and organic chemistry.
University of Washington faculty members engage in teaching, research, and service. Successful candidates will be expected to participate in undergraduate and graduate teaching and to develop innovative, vigorous, externally-funded research programs. Applicants must have a Ph.D. or domestic or foreign equivalent degree by date of appointment.
For information about the Department and to apply, please visit https://academicjobsonline.org/ajo/jobs/4322; applications should include a cover letter, curriculum vitae, statement of future research interests, and (at the Assistant Professor rank) three letters of reference. Priority will be given to applications received by October 3, 2014. Please direct all inquiries or disability accommodation requests to email@example.com.
The University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to, among other things, race, religion, color, national origin, sex, age, status as protected veterans, or status as qualified individuals with disabilities.
The Department of Chemistry congratulates Assistant Professor Bo Zhang on his promotion to associate professor with tenure, effective September 16, 2014.
Professor Zhang’s research focuses on the development and application of electroanalytical measurement tools to study single electrochemical events and processes. The Zhang group uses nanometer-scale electrodes to study electron transfer reactions of single molecules and single metal nanoparticles, electrocatalysis, and mass transport at the electrode/solution interface. This work is being conducted in pursuit of fundamental understanding of heterogeneous electron-transfer reactions and electrode/solution interfaces as well as single-cell chemistry and biological function such as neuronal secretion and brain activity.
To learn more about Professor Zhang’s research, please visit his faculty page and research group website.
The Department of Chemistry congratulates Assistant Professor Munira Khalil on her promotion to associate professor with tenure, effective September 16, 2014.
Professor Khalil’s research focuses on the development and application of advanced spectroscopic techniques to understand the ultrafast structural dynamics of light-driven chemical and biological processes in solution. Using multidimensional infrared (IR) and ultrafast x-ray absorption spectroscopies, the Khalil group studies how coupled electron and vibrational motions and their interactions with the surrounding solvent dictate the course of ultrafast charge transfer reactions in chemical and biological systems. This work will ultimately provide fundamental understanding of molecular energetics and the dynamics of chemical reactions, with broad practical applications in the design of new materials and molecular devices.
To learn more about Professor Khalil’s research, please visit her faculty page and her research group website.
Emeritus Professor Alvin Kwiram is among the 18 new members elected to the Washington State Academy of Sciences in recognition of their “outstanding record of scientific achievement and willingness to work on behalf of the Academy in bringing the best available science to bear on issues within the State of Washington.” The Washington State Academy of Sciences provides expert scientific and engineering analysis to inform public policy-making, and works to increase the role and visibility of science in the State of Washington. The new members, elected based on their achievements, will be inducted during the academy’s seventh annual meeting at the Seattle Museum of Flight on September 18, 2014. Thew newly elected members bring the academy’s total membership to 221.
WSAS Press Release: 18 New Members Elected by Science Academy
For more information about Professor Kwiram and his research, please visit his faculty page.
Emeritus Professor Gary Christian has been named a 2014 Fellow of the American Chemical Society. This honor is bestowed upon scientists “who have demonstrated outstanding accomplishments in chemistry and made important contributions to the American Chemical Society.” Professor Christian will be recognized at an induction ceremony during the 248th ACS National Meeting in San Francisco, CA in August 2014. A full list of 2014 ACS Fellows was published in Chemical & Engineering News.
The ACS Fellows Program was created by the ACS Board of Directors in December 2008 “to recognize members of ACS for outstanding achievements in and contributions to science, the profession, and the Society.” Fellows come from academe, industry, and government. More information about the ACS Fellows Program, including a complete list of all ACS Fellows, is available on the ACS Fellows website.
For more information about Professor Christian and his research, please visit his faculty page.
We are delighted to announce that Thom H. Dunning, Jr. will be joining the Department as Affiliate Professor of Chemistry.
Dr. Dunning is Co-Director of the Northwest Institute for Advanced Computing (NIAC), jointly founded in 2013 by Pacific Northwest National Laboratory and the University of Washington. NIAC, which has a physical location at the University of Washington, was established to advance the use of computing in discovery through a focus on research in big data, advanced computing, and high performance computing. Dr. Dunning is a leader in theoretical and computational chemistry, widely recognized for his expertise in electronic structure theory and scientific computing.
Dr. Dunning’s appointment is effective July 1, 2014. As Affiliate Professor of Chemistry with graduate faculty status, Professor Dunning will be able to serve as a graduate advisor, and his students will be located on the main University of Washington campus in Seattle.
For more information, please visit his faculty page, his NIAC staff page, or contact him directly via email at firstname.lastname@example.org.
We are delighted to announce that James J. De Yoreo will be joining the Department as Affiliate Professor of Chemistry.
Dr. De Yoreo is Chief Scientist for Fundamental Materials Science and Materials Synthesis and Simulation across Scales (MS3) at Pacific Northwest National Laboratory, and he is also affiliated with the UW Department of Materials Science & Engineering. Dr. De Yoreo is widely recognized for his pioneering research in materials science, with a research focus on macromolecular self-assembly, biomineralization, and biomimetic materials synthesis, and in situ imaging with transmission electron microscopy (TEM) and atomic force microscopy (AFM).
Dr. De Yoreo’s appointment is effective July 1, 2014. As Affiliate Professor of Chemistry with graduate faculty status, Dr. De Yoreo will be able to serve as a graduate advisor. Dr. De Yoreo’s primary laboratory facilities are located on the Pacific Northwest National Laboratory campus in Richland, WA.
For more information, please visit his faculty page, his PNNL staff page, or contact him directly via email at email@example.com.
We are delighted to announce that Dr. Lawrence Goldman will join the Department of Chemistry as Lecturer, with a focus on introductory organic chemistry lecture and laboratory courses.
Dr. Goldman received his undergraduate degree in chemistry and mathematics from Rutgers University, where he conducted research on organic synthesis with Prof. Spencer Knapp. He then received his Ph.D. in physical organic chemistry with Prof. Barry Carpenter at Cardiff University. Dr. Goldman has experience teaching organic chemistry lecture and laboratory courses at several institutions, and he will be moving to the UW from his current position as Visiting Assistant Professor at Whitman College.
We look forward to having Dr. Goldman join us in September as the fifth member of our lecturing faculty, and our first to specialize in organic chemistry instruction.