Affiliate Investigators

The DERC is a valuable resource for many investigators at the University of Washington as well as affiliated institutions in the greater Seattle Puget Sound region and nationally. These investigators can be found in the pages that are accessed by the menu on the right.

ABRASS, CHRISTINE, M.D.
Medicine (Nephrology)
Pathogenesis of Diabetic Nephropathy
Growth Factors and Messangial Cell Function
Glomerular Endothelial Cell Function in Diabetes

AGUILAR-BRYAN, LYDIA, M.D., Ph.D.
Pacific Northwest Research Institute
Molecular Basis for Hyperinsulinemic Hypoglycemia and Neonatal Diabetes in Newborns and Infants

ALBERS, JOHN, Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Lipoproteins in Health and Disease

AL-NOORI, SALWA, Ph.D.
Psychiatry & Behavioral Sciences
Dentate Gyrus Modulation of the Counter Regulatory Response to Recurrent Hypoglycemia

ALPERS, CHARLES, M.D.
Pathology
Development of a New Murine Model of Diabetic Nephropathy

ASKARI, BARDIA, Ph.D.
Pathology
The Role of Aldosterone in Macrophage Function in Diabetes Accelerated Atherosclerosis (P&F)

AUSTIN, MELISSA, Ph.D.
Epidemiology
Multi-Center Study of Pancreatic Cancer Etiology
Genetics of the Metabolic Syndrome in Japanese Americans

BABENKO, ANDREY, M.D., Ph.D.
Molecular Physiology and Biophysics
Studies of Mutant SUR1/Kir6.2 Channels Causing Human Neonatal Diabetes Mellitus

BASKIN, DENIS, Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Biological Structure
Insulin and Leptin Action in the Brain

BEAVO, JOSEPH, Ph.D.
Pharmacology
In Vivo Studies of Insulin and Leptin Signaling through Phosphodiesterase 3B
Studies on the Roles of Specific Cyclic Nucleotide Phosphodiesterases in Immune Cell Function

BLEVINS, JAMES, Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Leptin-Regulated Brain Pathways in Feeding and Obesity

BOND, GAIL, R.N., Ph.D.
Psychosocial and Community Health
Telehealth for Diabetes Self-Management

BORNFELDT, KARIN, Ph.D.
Pathology
Cellular Signaling in Diabetes-Accelerated Atherosclerosis

BOTHWELL, MARK, Ph.D.
Medicine (Phsyiology & Biophysics)
LIG Protein Regulators of Growth Factor Signaling in Pancreatic Beta Cells

BOWEN-POPE, DANIEL, Ph.D.
Pathology
Regulation of Insulin Secretion by Phogrin and IA-2

BOYKO, EDWARD, M.D., Ph.D.
Medicine
Japanese American Community Diabetes Study
A Prospective Study of Endothelial Dysfunction and Diabetic Foot Ulcer Risk
The Epidemiology of Foot Structure and Ulceration in Diabetic Veterans

BREMNER, WILLIAM, M.D., Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Hormone Contraception and Control of Testicular Function

BRUNZELL, JOHN, M.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Central Obesity Syndrome in a Subset of Type 1 Diabetes

BRYAN, JOSEPH, Ph.D.
Pacific Northwest Research Institute
Does Intraislet ZN2+, Co-Secreted with Insulin, Suppress Glucagon Release Via Activation of KATP?

CALLIS, JAMES, Ph.D.
Chemistry
The Islet Hospital: A Device for Non-Invasive Assessment and Purification of Human Islets

CARR, DARCY, M.D.
Obstetrics and Gynecology
Insulin Sensitivity, Hemodynamics, and Endothelial Function in Women with a History of Preeclampsia

CHAIT, ALAN, M.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Serum Amyloid A (SAA) and Diabetes
Lipoprotein Matrix Interactions in Diabetes

CHANG, MARY, Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Regular of Extracellular Matrix Synthesis by Factors Associated with Diabetes (P&F)
Regulation of Proteoglycans and Hyaluronan Synthesis in Human Monocyte-Derived Macrophages by Factors Associated with Diabetes

CHESSLER, STEVEN, M.D., Ph.D.
University of California, San Diego
GAD Release in Autoimmune Diabetes

CHITALEY, KANCHAN, Ph.D.
Urology
Erectile Dysfunction in Type 2 Diabetes: Role of Adiponectin

CONLEY, KEVIN, Ph.D.
Radiology and the Center for Bioengineering
Muscle Metabolism and Energetics in Type 2 Diabetes

COOK, DAVID, Ph.D.
Medicine (Gerontology)
Pharmacology
The Role of the Liver and Insulin Resistance in Regulating Peripheral A-beta Clearance

CRAFT, SUZANNE, Ph.D.
Psychiatry and Behavioral Sciences
The Effects of Rosiglitazone in Patients with MCI
Therapeutic Effects of Intranasal Insulin in AD
Insulin Resistance and CNS Function in Type 2 Diabetes
Insulin, Neurogenetics and Memory in Alzheimer's Disease: A Novel Therapeutic Approach
Glucose Regulation and Memory in Alzheimer's Disease
Insulin-Mediated Memory Facilitation in Alzheimer's Disease

CUMMINGS, DAVID, M.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Meal Initiation and Energy Homeostasis: Role of Ghrelin

D'ALESSIO, DAVID, M.D.
University of Cincinnati
The Role of GLP-1 on Normal and Abnormal Glucose Tolerance

deBOER, IAN, M.D.
Medicine
Pilot Clinical Trial of Vitamin D3 Therapy in the Metabolic Syndrome

DEEB, SAMIR, Ph.D.
Medicine, Medical Genetics
Genetic Variation Associated with Lipemic Response to Diet, Insulin Resistance and Obesity

DUNCAN, GLEN, Ph.D.
Epidemiology
Kinetics of Human Homocysteine Metabolism

DURVASALA, RAGHU, M.D.
Medicine (Nephrology)
Role of a Local Angiotensin System in Mediating Podocyte Injury in Diabetic Nephropathy (P&F)

ETTINGER, RUTH, Ph.D.
Immunology
MHC Class II Mediated Mechanisms of Type 1 Diabetes

FIGLEWICZ (LATTEMANN), DIANNE, Ph.D.
Psychiatry and Behavioral Sciences
Regulation of Brain Catecholamines by Insulin in Normal, Diabetic, and Obese Rats

FITZPATRICK, ANNETTE, Ph.D.
Epidemiology
A Twin Study of Inflammation and Obesity: Genetic and Environmental Influences (New Investigator Award)

FLUM, DAVID, M.D.
Surgery
Understanding Mechanisms of Weight Loss in Bariatric Surgery - Development of an Animal Model

FOSTER-SCHUBERT, KAREN, M.D.
Medicine
Effects of Food Energy Density on Appetite Hormones

GAUR, LAKSHMI, Ph.D.
WA National Primate Research Center
Induction of Tolerance to Islet Allografts in Primates

GREEN, PATTIE, Ph.D.
Medicine (Gerontology)
Modulation of Plasma Beta-Amyloid by Insulin

GREENBAUM, CARLA, M.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Benaroya Research Institute
Diabetes Prevention Trial - 1 (DPT-1)
Natural History of "Silent" Diabetes
Juvenile Diabetes Research Foundation International Center for Translational Research Clinical Core
DQB1 0602 Relatives: Mechanisms for Diabetes Protection

HAGOPIAN, WILLIAM, M.D., Ph.D.
Medicine (Metabolism, Endocrinology and Nutrition)
Pacific Northwest Research Institute
Prediction Pathogenesis and Prevention of Type 1 Diabetes in the General Population

HAMPE, CHRISTIANE, Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Epitopte-Specific GAD65 Monoclonal Antibodies Modulate GAD65 Antigen Processing and Presentation
GAD65 Ab in the NOD Mouse (P&F)

HAVEL, PETER, D.V.M., Ph.D.
Molecular Biosciences
School of Veterinary Medicine
University of California, Davis
Islet Morphology and Function in Rat Models of Obesity and Insulin Resistance

HEINECKE, JAY, M.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Mechanisms of Oxidative Stress in Diabetes

HILLE, BERTIL, Ph.D.
Physiology and Biophysics
Paracrine Effect of Fast Neurotransmitters on Insulin Secretion

HOCKENBERY, DAVID, M.D.
Medicine (Gastroenterology)
Fred Hutchinson Cancer Research Center
Bxl-XL Function

HOFFMAN, LUCAS, M.D., Ph.D.
Pediatrics
Mechanisms of Bacterial Antibiotic Resistance and Pathogenesis in Cystic Fibrosis

HULL, REBECCA, Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Role of Perlecan in Islet Amyloid Formation
Role of Matrix Metalloproteinases in Islet Amyloid Formation
Islet Amyloid Induces Islet B-Cell Death Through Increased Endoplasmic Reticulum Stress (P&F)

HURLEY, JAMES, Ph.D.
Biochemistry
Control of Photoreceptor Metabolism

IOANNOU, GEORGE, M.D.
Medicine (Gastroenterology)
Lipid Composition, Insulin Resistance, and Fatty Liver Disease

IYENGAR, SUDA, Ph.D.
Case Western Reserve University
Linkage Consortium End-Stage Renal Disease

JARVIK, GAIL, M.D., Ph.D.
Medicine and Medical Genetics
Family Studies of Lipoproteins and Coronary Disease

KAHN, STEVEN, M.B., Ch.B.
Medicine (Metabolism, Endocrinology & Nutrition)
Proinsulin and Islet Amyloid Polypeptide in States of Normal and Abnormal Islet Function
Type 2 Diabetes Primary Prevention Trial (Diabetes Prevention Program - DPP)
Look Ahead -- A Study of the Effect of Weight Loss on Health Outcomes in Subjects with Type 2 Diabetes

KANDEEL, FOUAD, M.D., Ph.D.
City of Hope National Medical Center
Assessment of Human Islet Quality

KIM, FRANCIS, M.D.
Medicine (Cardiology)
Glucose-Mediated Generation of Superoxide in Endothelial Cells

KIRK, ELIZABETH, Ph.D.
Pathobiology
Dietary Iron and Gene Regulation in Mice

KNOPP, ROBERT, M.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Effects of Insulin, Fuels, and Lipoproteins on Placental Cell Progesterone Secretion in Primary Tissue Culture and Effects of Sex Steroid Hormones on Endothelial Cell Oxidative Stress and Nitric Oxide Synthesis
Effects of Low-Fat, High Carbohydrate Diet in Men and Women
Effect of Insulin Resistance on the Lipoprotein Response to Egg Feeding
Diets for Dyslipidemia in the Metabolic Syndrome

KUSHMERICK, MARTIN, M.D. Ph.D.
Radiology
Mitochondrial Redox Quantification in Fast and Slow Twitch Murine Muscle

LA SPADA, ALBERT, M.D., Ph.D.
Laboratory Medicine, Medicine (Medical Genetics) and Neurology (Neurogenetics)
Role of PGC-1-alpha in Huntington's Disease Metabolic Abnormalities and Neurodegeneration

LADIGES, WARREN, D.V.M., M.S.
Comparative Medicine
Effects of Mitochondrial Catalase Expression in Protection of Islets

LEBOEUF, RENEE, Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Pathobiology
Development of Atherosclerosis in Diabetic Mice

LEDOUX, WILLIAM, Ph.D.
Mechanical Engineering
Orthopaedics and Sports Medicine
Changes in the Characteristics of Plantar Soft
Tissue with Diabetes

LEE, SUM PING, M.D., Ph.D.
Medicine (Gastroenterology)
Epidemiology of Gallbladder Sludge and Stones in Pregnancy

LERNMARK, ÅKE, Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Type 1 Diabetes Immunogenetics
Genetic Dissection of BB Rat Diabetes

MARCOVINA, SANTICA, Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Northwest Lipid Metabolism and Diabetes Research Laboratory

MCKNIGHT, STAN, Ph.D.
Pharmacology
Role of Protein Kinase A in Obesity and Diabetes

MCNEELY, MARGUERITE, M.D., M.P.H.
Medicine (Metabolism, Endocrinology & Nutrition)
Skeletal Muscle Fat and Risk of Type 2 Diabetes in Japanese Americans
Predictors and Correlates of Visceral Adiposity

MORALEJO, DANIEL, D.V.M., Ph.D.
Comparative Medicine
Role of Ian5, Cckar, and Lepr in Diabetes and Obesity Development in the Congenic Rat

MORTON, GREGORY, Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Effect of Hypothalamic Leptin Action on Glucose Metabolism (P&F)

NEPOM, GERALD, M.D., Ph.D.
Benaroya Research Institute
Immunology
Autoantigen-Specific T cells in IDDM

NGUYEN, TOAN, M.D.
Medicine (Gastroenterology)
Human Pancreatic Duct Cells: Culture and Characterization

OLERUD, JOHN, M.D.
Medicine (Dermatology)
The Roles for the Neurologic System and Laminin 5 in Wound Healing

ORAM, JOHN, Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Human Arterial Cells in Diabetes: Interactions with Lipoproteins and Regulation of Cell Cholesterol Metabolism

OSBORNE, WILLIAM, Ph.D.
Pediatrics
Gene Therapy for Diabetes

OSHIMA, JUNKO, Ph.D.
Pathology
Impact of Hapolinsufficiency in the Geriatric Population

PALMER, JERRY, M.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Trial Net Core Laboratories
Diabetes Control and Complications: Epidemiology of Diabetes Intervention and Complications (DCCT/EDIC)
Pathogenesis and Prevention of Type 1 Diabetes

PALMITER, RICHARD, Ph.D.
Biochemistry
Hormonal Responses to Hypoglycemia by Mice Lacking Ability to Make Norepinephrine

PARKS, TONY, M.D.
Pathology
A Novel Role for the Sorting Nexins in Caveolar Trafficking: Implications of Growth Factor Signaling in Vascular Smooth Muscle Cells

PIHOKER, CATHERINE, M.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Pediatrics (Pediatric Endocrinology)
SEARCH for Diabetes in Youth of the Puget Sound

QUINN, LEBRIS, Ph.D.
Medicine (Gerontology)
IL-15, Body Composition and Insulin Sensitivity in Aging

REEMS, JOANNA, Ph.D.
Puget Sound Blood Center
Culturing Human Pancreatic Islets and Assessing Their Functionality

REIBER, GAYLE, M.P.H., Ph.D.
Epidemiology
Diabetes Self Enhancement
Treatment Strategies for Patients with Diabetes at High Risk of Limb Loss
Improving Self-Management and Promoting Healthy Lifestyles in Medicaid and Dual Eligible Medicare Recipients with Diabetes

ROBERTSON, PAUL, M.D.
Medicine (Metabolism, Endocrinology & Nutrition) and Pharmacology
Pacific Northwest Research Institute
Pancreas and Islet Transplantation in Humans
Glucose Regulation of Pancreatic Islet Gene Expression

SANDERS, NICOLE, Ph.D.
Psychiatry and Behavioral Sciences
Central Nervous System Mechanism of Defective Hypoglycemia Counterregulation

SATIN, LES, Ph.D.
Virginia Commonwealth University
Oscillatory Mechanisms of Pancreatic Islets

SCHARENBERG, ANDREW, M.D.
Pediatrics
Analysis of the Role of LTRPC2 in Pancreatic B-Cell Function

SCHATZ, DESMOND, M.D.
Pediatrics, University of Florida
Autologous Cord Blood Transfusion to Reverse Hyperglycemia in Children with Type 1 Diabetes -- A Pilot Study

SCHWARTZ, MICHAEL, M.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Hormonal Regulation of Hypothalamic Neuropeptide Y in the Control of Energy Balance

SOBEL, MICHAEL, M.D., FACS
Surgery
Platelet Involvement in Inflammation and Thrombosis

STEINER, ROBERT, Ph.D.
Obstetrics and Gynecology
Physiology & Biophysics
Brain Genes Governing Reproduction

STORM, DANIEL, Ph.D.
Pharmacology
Type 3 Adenyl Cyclase Mutant Mice as a Model for Obesity

SUBRAMANIAN, SAVITHA, M.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Insulin Resistance and mTOR Inhibition

SWEET, IAN, Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Encapsulation of Pancreatic Islets with an Implantable Chamber
Role of Hypoxia in Death of Isolated Islets
Bioenergetics of Glucose-Induced Insulin Secretion in Pancreatic Islets

TABORSKY, GERALD, JR., Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Neural Regulation of Islet Function
Feasibility of Virally-Delivered Nerve Growth Factor (NGF) to Prevent Damage to Islet Sympathetic Nerves

TSAI, ELAINE CHIN-SAN, M.D., M.P.H.
Medicine (Metabolism, Endocrinology & Nutrition)
Identifying Risk Factors for Impaired Glucose Tolerance and Diabetes in Veterans with Central Obesity
Predictors of Subclinical Hepatic Steatosis in the Metabolic Syndrome

UTZSCHNEIDER, KRISTINA, M.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Insulin Resistance in Non-alcoholic Steatohepatitis

VAISAR, TOMAS, Ph.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Macrophage Derived Matrix Metalloproteinases in Diabetes Associated Atherosclerosis (P&F)

VITALIANO, PETER, Ph.D.
Psychiatry & Behavioral Sciences
Chronic Stress, Physiological Mediators and Coronary Disease

WANG, EDITH, Ph.D.
Pharmacology
Regulation and Function of TAF1 in Cellular Growth Control

WEIGLE, DAVID SCOTT, M.D.
Medicine (Metabolism, Endocrinology & Nutrition)
Role of Leptin in the Pathophysiology of Human Obesity
Metabolic Consequences of Aggressive Antiretroviral Therapy
Increased Omega-3 Fatty Acid Intake in the Treatment of Obesity
An Insulin Secretagogue from Adipose Tissue
Effect of Diet Composition on Body Weight Regulation

WESSELLS, HUNTER, M.D.
Urology
Neural Melanocortin Signaling and Erectile Function
Mechanisms of Diabetes Associated Penile Endothelial Dysfunction

WIGHT, THOMAS, Ph.D.
Benaroya Research Institute
Pathology
Amylin-Proteoglycan (Perlecan) Interaction in Diabetes

WISSE, BRENT, M.D.
Medicine (Metabolism, Endocrinology & Nutrition)
The Role NF-KB Signaling in Central Leptin Resistance
Melanocortins, Energy Balance and Cancer Anorexia

XU, WENQING, Ph.D.
Biological Structure
Crystallographic Studies of Protein Kinase B