UW CHEMISTRY NMR

Dear Users

For the benefit of those of you who might have missed my last call on the topic, please click on the link below.

SNAP POLL: GG500’s NEW BBFO iProbe – SOLICITING YOUR INPUT

 

I renew the call above and request you to email to : rajanp@uw.edu about which of the three software interfaces you will be comfortable with and a couple of lines of what motivated you with that choice.  The choices are :

1. Traditional Topspin Interface
2. Routine Spectroscopy interface that is currently driving the GG500
3. Full Automation suite, very similar to what is driving NEO500

I would emphasize that, no matter which one you prefer, complete control of the spectrometer parameters and interaction are possible with any of the three. Only the methods differ. Rest assured, we will train you to become adept with the same. 

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We are ready to deploy the brand new iProbe that has the capability to record spectra for a range of X-nuclei from 31P to 109Ag (~202.5 MHz to 23.3 MHz)  AS WELL AS 19F (~470.5 MHz). 

I emphasize the “AS WELL AS” here because, the similar looking Prodigy probe on NEO500 cannot excite both 1H and 19F nuclei simultaneously.   What does this mean to you :

• You can record 19F 1D experiments with 1H broadband decoupling to remove J(H-F) coupling.
• You can think of correlation experiments between 1H and 19F, that use simultaneous pulses for coherence transfer i.e. similar to 1H-13C HSQC sequences
• You can think of XHCORR family of experiments, where 19F will be the direct dimension and 1H will be the indirect dimension, i.e. giving you the highest resolution along 19F axis, preserving J-FH coupling information in the 2D plane.

If you come across any other complex pulse sequences for 19F spectroscopy, please contact us, and I am confident that this hardware can handle the same.

NMR Facility Manager

4/24/2023